The laboratory is seeking highly motivated young scientists interested in the broad area of membrane proteins and lipid dynamics. The Barrera laboratory uses biophysical, cell biology, biochemical and computational approaches to unravel the molecular mechanism of diverse membrane processes. Available projects include: 1) determination of the activation mechanism of receptor tyrosine kinases, 2) design of tumor targeting peptides, and 3) elucidation of the molecular mechanism of a new bacterial protein that regulates lipid metabolism.
The R01-funded Barrera Lab is located in the newly constructed Mossman Building within the Department of Biochemistry & Cellular and Molecular Biology at the University of Tennessee. The University is located in downtown Knoxville, situated a mere 30 minutes away from the Great Smoky Mountains National Park. The group is member of a vibrant and large Biomembranes Community of Scholars, and is highly collaborative, including with members of the nearby Oak Ridge National Laboratory.
We offer an excellent research environment and dedicated mentoring, including the development and following of an Individual Development Plan, in an area with high quality of life and reasonable cost of living.
Review of applications will begin immediately and continue until the position is filled. Interested candidates will send a CV and the names, email addresses, and telephone numbers of at least three references to Associate Professor Fran Barrera (firstname.lastname@example.org). Follow updates at @BarreraLab.
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The plasma membrane constitutes the boundary that delineates communication between cells and their environment. As a consequence, any cell-based therapy entails interaction with membrane components. In fact, half of the currently used drugs target membrane proteins, primarily receptors. The study of cellular membranes is living a sustained growth, and important discoveries are being made establishing the biological relevance of this vital entity. Intense areas of study include lipid regulation of membrane protein structure of function, membrane nanodomains, the dynamic interplay of peripheral membrane proteins and the formation of membrane protein complexes. The Barrera laboratory uses biophysical, biochemical, molecular biology, cell biology and computational tools to investigate the interplay between proteins and lipids in systems of biomedical relevance.