Publications

Barrera lab undergraduate and graduate students are highlighted
2018
  1. Daiane S Alves, Justin M Westerfield, Xiaojun Shi, Vanessa P Nguyen, Katherine M Stefanski, Kristen R Booth, Soyeon Kim, Jennifer Morrell-Falvey, Bing-Cheng Wang, Steven M Abel, Adam W Smith, Francisco N Barrera “A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration.” eLife (2018). PMID: 30222105

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  1. Tanei J. Ricks, Chelsi D. Cassilly, Adam J. Carr, Daiane S. Alves, Shahrina Alam, Kathrin Tscherch, Timothy W. Yokley, Cameron E. Workman, Jennifer L. Morrell‐Falvey, Francisco N. Barrera, Todd B. Reynolds, Michael D. Best. “Labeling of Phosphatidylinositol Lipid Products in Cells through Metabolic Engineering by Using a Clickable myo‐Inositol Probe.” ChemBioChem (2018). PMID: 30098105

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  1. Zhang X, Alves DS, Lou J, Hill SD, Barrera FN, and Best MD. “Boronic acid liposomes for cellular delivery and content release driven by carbohydrate binding.Chem Comm (2018). PMID: 29809225

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  1. Usery RD, Enoki TA, Wickramasinghe SP, Nguyen VP, Ackerman DG, Greathouse DV, Koeppe RE, Barrera FN, and Feigenson GW. “Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide.” Biophysical Journal (2018). PMID: 29742408

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 2017
  1. Alexander G. Karabadzhak, Lisa M. Petti, Francisco N. Barrera, Anne P. B. Edwards, Andrés Moya-Rodríguez, Yury S. Polikanov, J. Alfredo Freites, Douglas J. Tobias, Donald M. Engelman, and Daniel DiMaio. “Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation.” Proceedings of the National Academy of Sciences (2017). PMID: 28808001

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  1. Haden L. Scott, Justin M. Westerfield, and Francisco N. Barrera. “Determination of the Membrane Translocation pK of the pH-Low Insertion Peptide.” Biophysical Journal (2017). PMID: 28834723

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 2015
  1. Vanessa P. Nguyen, Daiane S. Alves, Haden L. Scott, Forrest L. Davis, and Francisco N. Barrera. “A Novel Soluble Peptide with pH-Responsive Membrane Insertion.” Biochemistry (2015). PMID: 26497400    *Editor’s Choice

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  1. Alam, Shahrina, Daiane Santana Alves, Stuart A. Whitehead, Andrew Michael Bayer, Christopher D. McNitt, Vladimir V. Popik, Francisco Nicolas Barrera, and Michael D. Best. “A Clickable and Photocleavable Lipid Analog for Cell Membrane Delivery and Release.” Bioconjugate chemistry (2015). PMID: 25927978

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  1. Scott, Haden L., Vanessa P. Nguyen, Daiane S. Alves, Forrest L. Davis, Kristen R. Booth, Jordan Bryner, and Francisco N. Barrera. “The Negative Charge of the Membrane Has Opposite Effects on the Membrane Entry and Exit of pH-Low Insertion Peptide.” Biochemistry 54, no. 9 (2015): 1709-1712. PMID:25692747

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  1. Cheng, Christopher, Raman Bahal, Imran Babar, Zachary Pincus, Francisco Barrera, Connie Liu, Alexander Svoronos, Demetrios Braddock, Peter Glazer, Donald Engelman, W. Saltzman, and Frank Slack. “MicroRNA Silencing for Cancer Therapy Targeted to the Tumour Microenvironment.” Nature 518.7537 (2014): 107-10. PMID:25409146

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  1. Deacon, John, Donald Engelman, and Francisco Barrera. “Targeting Acidity in Diseased Tissues; Mechanism and Applications of the Membrane-inserting Peptide, pHLIP.” Archives of Biochemistry and Biophysics 565 (2015): 40-48. PMID:25444855

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2014

  1. CohenEB, Jun SJ, Bears Z, Barrera FN, AlonsoM, Engelman DM, DiMaio D. Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. PLoS One2014. PMID: 24788775

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  1. Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD. Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. J Virol.2014; 88: 625-42. PMID: 24173222

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2013

  1. Fendos J, Barrera FN Engelman DM. Aspartate Embedding Depth Affects pHLIP’s Insertion pKa. Biochemistry2013; 52, 4595-604. PMID: 23721379  Highlighted on the journal

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2012

  1. Barrera FN, Fendos J, Engelman DM. Membrane physical properties influence transmembrane helix formation. Proc Natl Acad Sci USA2012; 109: 14422-7. PMID: 22908237

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2011

  1. Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM. Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol.2011;413:359-71. PMID: 21888917

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2010

  1. Cammett TJ, Jun SJ, Cohen EB, Barrera FN, Engelman DM, DiMaio D. Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc Natl Acad Sci USA. 2010;107:3447-52. PMID: 20142506

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  1. Triano I, Barrera FN, Renart ML, Molina ML, Fernandez-Ballester G, Poveda JA, Fernandez AM, Encinar JA, Ferrer-Montiel AV, Otzen D, Gonzalez-Ros JM. Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein. Biochemistry. 2010;49:5397-404. PMID: 20481584

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2009

  1. Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, DiMaio D. Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. J Virol. 2009;83:9773-85. PMID: 19605488

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  1. Neira JL, Roman-Trufero M, Contreras LM, Prieto J, Singh G, Barrera FN, Renart ML, Vidal M. The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA. Biochemistry. 2009;48:1348-60. PMID: 19170609

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2008

  1. Molina ML, Barrera FN*, Encinar JA, Renart ML, Fernandez AM, Poveda JA, Santoro J, Bruix M, Gavilanes F, Fernandez-Ballester G, Neira JL, Gonzalez-Ros JM. N-type inactivation of the potassium channel KcsA by the Shaker B “ball” peptide: mapping the inactivating peptide-binding epitope. J Biol Chem. 2008;283:18076-85. PMID:  18430729

*Co-first author.

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  1. Barrera FN, Renart ML, Poveda JA, de Kruijff B, Killian JA, Gonzalez-Ros JM. Protein self-assembly and lipid binding in the folding of the potassium channel KcsA. Biochemistry. 2008;47:2123-33. PMID: 18205389

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  1. Barrera FN*, del Alamo M, Mateu MG, Neira JL. Envelope lipids regulate the in vitro assembly of the HIV-capsid. Biophysical J.2008;94:L8-10. PMID: 17981892

      Corresponding author.

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2007

  1. Alcaraz LA, Del Alamo M, Barrera FN, Mateu MG, Neira JL. Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein. Biophys J. 2007;93:1264-76. PMID: 17526561

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  1. Czypionka A, de los Panos OR, Mateu MG, Barrera FN, Hurtado-Gomez E, Gomez J, Vidal M, Neira JL. The isolated C-terminal domain of Ring1B is a dimer made of stable, well-structured monomers. Biochemistry. 2007;46:12764-76. PMID: 17935356

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2006

  1. Renart ML, Barrera FN, Molina ML, Encinar JA, Poveda JA, Fernandez AM, Gomez J, Gonzalez-Ros JM. Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA. J Biol Chem. 2006;281:29905-15. PMID: 16815844

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  1. Molina ML, Barrera FN, Fernandez AM, Poveda JA, Renart ML, Encinar JA, Riquelme G, Gonzalez-Ros JM. Clustering and coupled gating modulate the activity in KcsA, a potassium channel model. J Biol Chem. 2006;281:18837-48. PMID: 16670090

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  1. Barrera FN, Hurtado-Gomez E, Lidon-Moya MC, Neira JL. Binding of the C-terminal domain of the HIV-1 capsid protein to lipid membranes: a biophysical characterization. Biochem J. 2006;394:345-53. PMID: 16259620

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2005

  1. Hernandez JA, Meier J, Barrera FN, de los Panos OR, Hurtado-Gomez E, Bes MT, Fillat MF, Peleato ML, Cavasotto CN, Neira JL. The conformational stability and thermodynamics of Fur A (ferric uptake regulator) from Anabaenasp. PCC 7119. Biophys J. 2005;89:4188-200. PMID: 16169981

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  1. Barrera FN, Renart ML, Molina ML, Poveda JA, Encinar JA, Fernandez AM, Neira JL, Gonzalez-Ros JM. Unfolding and refolding in vitroof a tetrameric, alpha-helical membrane protein: the prokaryotic potassium channel KcsA. Biochemistry. 2005;44:14344-52. PMID: 16245951

     Considered of “special interest” in: Current Opinion in Structural Biology 2006, 16:480–488

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  1. Lidon-Moya MC, Barrera FN, Bueno M, Perez-Jimenez R, Sancho J, Mateu MG, Neira JL. An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein. Protein Sci. 2005;14:2387-404. PMID: 16131662

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  1. Encinar JA, Molina ML, Poveda JA, Barrera FN, Renart ML, Fernandez AM, Gonzalez-Ros JM. The influence of a membrane environment on the structure and stability of a prokaryotic potassium channel, KcsA. FEBS Lett. 2005;579:5199-204. PMID: 16150445

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  1. Hurtado-Gomez E, Barrera FN, Neira JL. Structure and conformational stability of the enzyme I ofStreptomyces coelicolor explored by FTIR and circular dichroism. Biophys Chem. 2005;115:229-33. PMID: 15752610

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2004

  1. Molina ML, Encinar JA, Barrera FN, Fernandez-Ballester G, Riquelme G, Gonzalez-Ros JM. Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA. Biochemistry. 2004;43:14924-31. PMID:  15554699

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  1. Garzon MT, Lidon-Moya MC, Barrera FN, Prieto A, Gomez J, Mateu MG, Neira JL. The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization. Protein Sci. 2004;13:1512-23. PMID: 15152086

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2003

  1. Barrera FN, Poveda JA, Gonzalez-Ros JM, Neira JL. Binding of the C-terminal SAM domain of human p73 to lipid membranes. J Biol Chem. 2003;21:46878-85 PMID: 12954612

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  1. Muro-Pastor MI, Barrera FN, Reyes JC, Florencio FJ, Neira JL. The inactivating factor of glutamine synthetase, IF7, is a “natively unfolded” protein. Protein Sci.2003;12:1443-54. PMID: 12824490

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2002

  1. Barrera FN, Garzon MT, Gomez J, Neira JL. Equilibrium unfolding of the C-terminal SAM domain of p73. Biochemistry. 2002;41:5743-53. PMID: 11980478

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                      Invited Reviews and Correspondence

  1. Barrera FN, Neira JL. Turbulent times in southern European science. Lancet. 2013; 380:1229-30

PMID: 23040858

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  1. Barrera FN, Alcaraz LA, Hurtado-Gomez E, Neira JL. Into the lipid realm: stability and thermodynamics of membrane proteins. Curr Protein Pept Sci. 2008;9:626-37. PMID : 19075751

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